muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1124 |
4. Check minimum number of eventsNone |
1124 |
5. Include endpointsNone |
1124 |
6. Filter based on genotype QC (FinnGen only) |
1073 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M62
Name in latin
Distensio musculi
Similar endpoints
↥List of similar endpoints to
Muscle strain
based on the number of shared cases.
Similar with more cases:
- Disorders of muscles
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11393 | 5255 | 6071 |
| Only index persons | 10885 | 5060 | 5825 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.15 | 0.17 |
| Only index persons | 0.21 | 0.19 | 0.22 |
| Median age at first event (years) | |||
| Whole population | 41.67 | 43.15 | 40.44 |
| Only index persons | 42.06 | 43.53 | 40.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1073 | 616 | 457 |
| Unadjusted period prevalence (%) | 0.24 | 0.24 | 0.23 |
| Median age at first event (years) | 50.17 | 48.48 | 52.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_MUSCLESTRAIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MUSCLESTRAIN | 1.129 [0.95, 1.34] | 0.17 |
| Birth year | 0.995 [0.99, 1.0] | 0.281 |
During the follow-up period (1.1.1998 — 31.12.2019), 321 out of 4277 females with M13_MUSCLESTRAIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MUSCLESTRAIN | 1.068 [0.9, 1.27] | 0.465 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 365 out of 4901 males with M13_MUSCLESTRAIN died.
Mortality risk
Mortality risk for people of age
years, who have M13_MUSCLESTRAIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.136% | 0.164% |
| 5 | 0.711% | 1.296% |
| 10 | 1.856% | 2.923% |
| 15 | 3.398% | 5.774% |
| 20 | 6.021% | 9.868% |
Relationships between endpoints
↥Index endpoint: M13_MUSCLESTRAIN – Muscle strain
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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