muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
130 |
4. Check minimum number of eventsNone |
130 |
5. Include endpointsNone |
130 |
6. Filter based on genotype QC (FinnGen only) |
128 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M62
Name in latin
Contractura musculi
Similar endpoints
↥List of similar endpoints to
Contracture of muscle
based on the number of shared cases.
Similar with more cases:
- Increased muscle tone
- Disorders of muscles
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1175 | 667 | 502 |
| Only index persons | 1106 | 642 | 464 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 46.18 | 48.13 | 43.55 |
| Only index persons | 46.00 | 48.18 | 42.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 128 | 85 | 43 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 55.72 | 53.15 | 60.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_MUSCONTRAC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MUSCONTRAC | 1.421 [0.96, 2.1] | 0.078 |
| Birth year | 0.995 [0.99, 1.0] | 0.284 |
During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 551 females with M13_MUSCONTRAC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MUSCONTRAC | 1.473 [1.01, 2.14] | 0.043 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 432 males with M13_MUSCONTRAC died.
Mortality risk
Mortality risk for people of age
years, who have M13_MUSCONTRAC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.125% | 0.285% |
| 5 | 0.741% | 1.557% |
| 10 | 2.007% | 3.941% |
| 15 | 3.94% | 7.491% |
| 20 | 7.177% | 13.183% |
Relationships between endpoints
↥Index endpoint: M13_MUSCONTRAC – Contracture of muscle
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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