No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
56594 |
4. Check minimum number of eventsNone |
56594 |
5. Include endpoints |
68295 |
6. Filter based on genotype QC (FinnGen only) |
65892 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Hernia
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 651736 | 192933 | 453240 |
| Only index persons | 550498 | 166988 | 383510 |
| Unadjusted period prevalence (%) | |||
| Whole population | 10.49 | 5.53 | 12.66 |
| Only index persons | 12.06 | 6.14 | 14.64 |
| Median age at first event (years) | |||
| Whole population | 53.07 | 55.76 | 51.84 |
| Only index persons | 51.19 | 54.12 | 49.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 65892 | 21699 | 44193 |
| Unadjusted period prevalence (%) | 17.69 | 8.52 | 22.19 |
| Median age at first event (years) | 54.67 | 53.45 | 55.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_HERNIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_HERNIA | 1.258 [1.16, 1.36] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.136 |
During the follow-up period (1.1.1998 — 31.12.2019), 23331 out of 119961 females with K11_HERNIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_HERNIA | 1.054 [0.98, 1.14] | 0.185 |
| Birth year | 0.985 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 46143 out of 255430 males with K11_HERNIA died.
Mortality risk
Mortality risk for people of age
years, who have K11_HERNIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.12% | 0.141% |
| 5 | 0.723% | 0.989% |
| 10 | 1.65% | 2.484% |
| 15 | 3.249% | 4.818% |
| 20 | 5.686% | 8.422% |
Relationships between endpoints
↥Index endpoint: K11_HERNIA – Hernia
GWS hits: 78
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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