No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
10956 |
4. Check minimum number of eventsNone |
10956 |
5. Include endpointsNone |
10956 |
6. Filter based on genotype QC (FinnGen only) |
10575 |
Control definitions (FinnGen only)
Control exclude
K11_HERNIA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K40-K46
Name in latin
Hernia umbilicalis
Similar endpoints
↥List of similar endpoints to
Umbilical hernia
based on the number of shared cases.
Similar with more cases:
- Hernia of abdominal wall
- Hernia
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 94059 | 38411 | 55127 |
| Only index persons | 82621 | 32473 | 50148 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.36 | 1.10 | 1.54 |
| Only index persons | 1.63 | 1.19 | 1.91 |
| Median age at first event (years) | |||
| Whole population | 51.12 | 49.21 | 52.41 |
| Only index persons | 50.20 | 46.79 | 52.41 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10575 | 4157 | 6418 |
| Unadjusted period prevalence (%) | 2.60 | 1.63 | 3.22 |
| Median age at first event (years) | 52.12 | 46.47 | 55.78 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_UMBHER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_UMBHER | 1.372 [1.25, 1.5] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.32 |
During the follow-up period (1.1.1998 — 31.12.2019), 3717 out of 24844 females with K11_UMBHER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_UMBHER | 1.293 [1.18, 1.42] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 5360 out of 42052 males with K11_UMBHER died.
Mortality risk
Mortality risk for people of age
years, who have K11_UMBHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.125% | 0.197% |
| 5 | 0.741% | 1.255% |
| 10 | 2.042% | 3.408% |
| 15 | 4.222% | 6.527% |
| 20 | 7.503% | 10.963% |
Relationships between endpoints
↥Index endpoint: K11_UMBHER – Umbilical hernia
GWS hits: 30
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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