No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
19497 |
6. Filter based on genotype QC (FinnGen only) |
18835 |
Control definitions (FinnGen only)
Control exclude
ABDOM_HERNIA_POSTOP
Extra metadata
First used in FinnGen datafreeze
DF3
Hernia of abdominal wall
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 165926 | 78238 | 86523 |
| Only index persons | 140855 | 65540 | 75315 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.33 | 2.24 | 2.42 |
| Only index persons | 2.66 | 2.41 | 2.88 |
| Median age at first event (years) | |||
| Whole population | 54.58 | 55.10 | 54.07 |
| Only index persons | 53.24 | 52.94 | 53.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 18835 | 8668 | 10167 |
| Unadjusted period prevalence (%) | 4.32 | 3.40 | 5.11 |
| Median age at first event (years) | 54.73 | 51.88 | 57.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ABDOM_HERNIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ABDOM_HERNIA | 1.404 [1.29, 1.52] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.041 |
During the follow-up period (1.1.1998 — 31.12.2019), 9514 out of 50056 females with ABDOM_HERNIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ABDOM_HERNIA | 1.296 [1.19, 1.41] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 10727 out of 61938 males with ABDOM_HERNIA died.
Mortality risk
Mortality risk for people of age
years, who have ABDOM_HERNIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.114% | 0.252% |
| 5 | 0.675% | 1.493% |
| 10 | 1.748% | 3.669% |
| 15 | 3.403% | 7.049% |
| 20 | 5.776% | 11.76% |
Relationships between endpoints
↥Index endpoint: ABDOM_HERNIA – Hernia of abdominal wall
GWS hits: 27
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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