Hernia of abdominal wall, postoperative

ABDOM_HERNIA_POSTOP

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • GAST_OPER
  • ==1
  • and GAST_OPER_AGE
  • <ABDOM_HERNIA_AGE
7408

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

7408

6. Filter based on genotype QC (FinnGen only)

7161

Control definitions (FinnGen only)

Control exclude K11_HERNIA
Control conditions not GAST_OPER

Extra metadata

First used in FinnGen datafreeze DF3

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 43684 20791 22742
Only index persons 41349 19880 21469
Unadjusted period prevalence (%)
Whole population 0.61 0.60 0.64
Only index persons 0.78 0.73 0.82
Median age at first event (years)
Whole population 61.66 62.18 61.18
Only index persons 61.47 61.87 61.09

-FinnGen-

Key figures

All Female Male
Number of individuals 7161 3511 3650
Unadjusted period prevalence (%) 1.61 1.38 1.83
Median age at first event (years) 61.27 59.01 63.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint ABDOM_HERNIA_POSTOP and mortality.

Females

Parameter HR [95% CI] p-value
ABDOM_HERNIA_POSTOP 1.539 [1.4, 1.69] < 0.001
Birth year 0.996 [0.99, 1.0] 0.367

During the follow-up period (1.1.1998 — 31.12.2019), 3641 out of 17851 females with ABDOM_HERNIA_POSTOP died.

Males

Parameter HR [95% CI] p-value
ABDOM_HERNIA_POSTOP 1.6 [1.44, 1.77] < 0.001
Birth year 0.989 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 4381 out of 19478 males with ABDOM_HERNIA_POSTOP died.

Mortality risk

Mortality risk for people of age

years, who have ABDOM_HERNIA_POSTOP.

N-year risk Females Males
1 0.173% 0.304%
5 0.978% 1.866%
10 2.468% 4.95%
15 4.37% 9.525%
20 7.873% 15.084%

Relationships between endpoints

Index endpoint: ABDOM_HERNIA_POSTOP – Hernia of abdominal wall, postoperative

GWS hits: 7

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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