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Inguinal hernia

DOID EFO Endpoint Browser PheWeb

K11_HERING

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K40
  • Hospital discharge: ICD-9 — 550
  • Hospital discharge: ICD-8 — 550
  • Cause of death: ICD-10 — K40
  • Cause of death: ICD-9 — 550
  • Cause of death: ICD-8 — 550

2 out of 7 registries used, show all original rules.

40001

4. Check minimum number of events

None

40001

5. Include endpoints

None

40001

6. Filter based on genotype QC (FinnGen only)

38606

Control definitions (FinnGen only)

Control exclude K11_HERNIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K40-K46
Name in latin Hernia inguinalis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 420960 62072 354893
Only index persons 351616 53399 298217
Unadjusted period prevalence (%)
Whole population 8.66 1.78 9.92
Only index persons 9.95 1.96 11.38
Median age at first event (years)
Whole population 50.45 45.13 51.25
Only index persons 47.81 42.61 48.74

-FinnGen-

Key figures

All Female Male
Number of individuals 38606 5772 32834
Unadjusted period prevalence (%) 14.36 2.27 16.49
Median age at first event (years) 52.86 41.64 54.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_HERING and mortality.

Females

Parameter HR [95% CI] p-value
K11_HERING 1.057 [0.98, 1.14] 0.173
Birth year 0.994 [0.99, 1.0] 0.152

During the follow-up period (1.1.1998 — 31.12.2019), 5338 out of 29603 females with K11_HERING died.

Males

Parameter HR [95% CI] p-value
K11_HERING 0.938 [0.87, 1.01] 0.103
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 32563 out of 184849 males with K11_HERING died.

Mortality risk

Mortality risk for people of age

years, who have K11_HERING.

N-year risk Females Males
1 0.1% 0.166%
5 0.663% 0.927%
10 1.602% 2.474%
15 2.839% 4.48%
20 4.904% 7.641%

Relationships between endpoints

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Index endpoint: K11_HERING – Inguinal hernia

GWS hits: 88

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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