No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3758 |
4. Check minimum number of eventsNone |
3758 |
5. Include endpointsNone |
3758 |
6. Filter based on genotype QC (FinnGen only) |
3625 |
Control definitions (FinnGen only)
Control exclude
K11_HERNIA
Extra metadata
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Inguinal hernia, bilateral
based on the number of shared cases.
Similar with more cases:
- Inguinal or femoral hernia, bilateral
- Inguinal hernia
- Hernia
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 32945 | 3598 | 29171 |
| Only index persons | 30071 | 3207 | 26864 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.73 | 0.10 | 0.82 |
| Only index persons | 0.93 | 0.12 | 1.03 |
| Median age at first event (years) | |||
| Whole population | 60.00 | 58.80 | 60.10 |
| Only index persons | 59.60 | 58.64 | 59.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3625 | 362 | 3263 |
| Unadjusted period prevalence (%) | 1.49 | 0.14 | 1.64 |
| Median age at first event (years) | 62.20 | 55.30 | 62.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint HERING_BILATERAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| HERING_BILATERAL | 1.146 [1.01, 1.3] | 0.038 |
| Birth year | 0.993 [0.98, 1.0] | 0.095 |
During the follow-up period (1.1.1998 — 31.12.2019), 657 out of 3063 females with HERING_BILATERAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| HERING_BILATERAL | 0.986 [0.91, 1.07] | 0.741 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 5117 out of 25068 males with HERING_BILATERAL died.
Mortality risk
Mortality risk for people of age
years, who have HERING_BILATERAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.08% | 0.224% |
| 5 | 0.647% | 1.255% |
| 10 | 1.526% | 3.107% |
| 15 | 2.9% | 5.815% |
| 20 | 5.48% | 9.394% |
Relationships between endpoints
↥Index endpoint: HERING_BILATERAL – Inguinal hernia, bilateral
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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