No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1532 |
4. Check minimum number of eventsNone |
1532 |
5. Include endpointsNone |
1532 |
6. Filter based on genotype QC (FinnGen only) |
1483 |
Control definitions (FinnGen only)
Control exclude
K11_HERNIA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K40-K46
Name in latin
Hernia femoralis
Femoral hernia
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16909 | 10051 | 6717 |
| Only index persons | 13103 | 7980 | 5123 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.29 | 0.19 |
| Only index persons | 0.26 | 0.29 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 57.75 | 58.94 | 55.78 |
| Only index persons | 54.00 | 54.97 | 52.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1483 | 818 | 665 |
| Unadjusted period prevalence (%) | 0.33 | 0.32 | 0.33 |
| Median age at first event (years) | 52.33 | 50.30 | 54.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_FEMHER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_FEMHER | 1.32 [1.19, 1.47] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.14 |
During the follow-up period (1.1.1998 — 31.12.2019), 1345 out of 4553 females with K11_FEMHER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_FEMHER | 1.088 [0.97, 1.22] | 0.154 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 907 out of 3097 males with K11_FEMHER died.
Mortality risk
Mortality risk for people of age
years, who have K11_FEMHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.138% | 0.184% |
| 5 | 0.714% | 1.181% |
| 10 | 1.955% | 3.021% |
| 15 | 3.699% | 5.616% |
| 20 | 6.236% | 9.907% |
Relationships between endpoints
↥Index endpoint: K11_FEMHER – Femoral hernia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data