sinusitis: An acute or chronic inflammatory process affecting the mucous membranes of any sinus cavity.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
62782 |
4. Check minimum number of eventsNone |
62782 |
5. Include endpoints |
90638 |
6. Filter based on genotype QC (FinnGen only) |
87268 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Acute upper respiratory infections
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1237557 | 506172 | 726277 |
| Only index persons | 1001195 | 403187 | 598008 |
| Unadjusted period prevalence (%) | |||
| Whole population | 17.86 | 14.50 | 20.29 |
| Only index persons | 19.60 | 14.82 | 22.83 |
| Median age at first event (years) | |||
| Whole population | 20.30 | 21.19 | 19.54 |
| Only index persons | 22.16 | 25.66 | 19.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 87268 | 43379 | 43889 |
| Unadjusted period prevalence (%) | 19.55 | 17.04 | 22.04 |
| Median age at first event (years) | 27.44 | 34.53 | 20.43 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_UPPERINFEC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_UPPERINFEC | 1.637 [1.49, 1.8] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.302 |
During the follow-up period (1.1.1998 — 31.12.2019), 32428 out of 361795 females with J10_UPPERINFEC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_UPPERINFEC | 1.845 [1.66, 2.04] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 29451 out of 357433 males with J10_UPPERINFEC died.
Mortality risk
Mortality risk for people of age
years, who have J10_UPPERINFEC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.21% | 0.358% |
| 5 | 0.99% | 1.911% |
| 10 | 2.309% | 4.847% |
| 15 | 4.58% | 9.08% |
| 20 | 8.19% | 15.213% |
Relationships between endpoints
↥Index endpoint: J10_UPPERINFEC – Acute upper respiratory infections
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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