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Acute epiglottitis

DOID EFO Endpoint Browser PheWeb

J10_EPIGLOTTITIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J05.1
  • Hospital discharge: ICD-9 — 4643
  • Hospital discharge: ICD-8 — 46404
  • Cause of death: ICD-10 — J05.1
  • Cause of death: ICD-9 — 4643
  • Cause of death: ICD-8 — 46404

2 out of 7 registries used, show all original rules.

518

4. Check minimum number of events

None

518

5. Include endpoints

None

518

6. Filter based on genotype QC (FinnGen only)

497

Control definitions (FinnGen only)

Control exclude J10_UPPERINFEC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J05
Name in latin Epiglottitis acuta

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5000 2010 2955
Only index persons 4606 1904 2702
Unadjusted period prevalence (%)
Whole population 0.07 0.06 0.08
Only index persons 0.09 0.07 0.10
Median age at first event (years)
Whole population 41.89 40.32 42.82
Only index persons 41.03 39.96 41.78

-FinnGen-

Key figures

All Female Male
Number of individuals 497 232 265
Unadjusted period prevalence (%) 0.11 0.09 0.13
Median age at first event (years) 45.25 38.63 51.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint J10_EPIGLOTTITIS and mortality.

Females

Parameter HR [95% CI] p-value
J10_EPIGLOTTITIS 1.186 [0.94, 1.5] 0.152
Birth year 0.993 [0.98, 1.0] 0.127

During the follow-up period (1.1.1998 — 31.12.2019), 121 out of 1403 females with J10_EPIGLOTTITIS died.

Males

Parameter HR [95% CI] p-value
J10_EPIGLOTTITIS 1.459 [1.22, 1.74] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 282 out of 1993 males with J10_EPIGLOTTITIS died.

Mortality risk

Mortality risk for people of age

years, who have J10_EPIGLOTTITIS.

N-year risk Females Males
1 0.084% 0.284%
5 0.639% 1.731%
10 1.61% 4.157%
15 3.083% 7.877%
20 5.572% 13.424%

Relationships between endpoints

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Index endpoint: J10_EPIGLOTTITIS – Acute epiglottitis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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