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Acute sinusitis

DOID EFO Endpoint Browser PheWeb

J10_SINUSITIS

sinusitis: An acute or chronic inflammatory process affecting the mucous membranes of any sinus cavity.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J01
  • Hospital discharge: ICD-9 — 461
  • Hospital discharge: ICD-8 — 461
  • Cause of death: ICD-10 — J01
  • Cause of death: ICD-9 — 461
  • Cause of death: ICD-8 — 461

2 out of 7 registries used, show all original rules.

26472

4. Check minimum number of events

None

26472

5. Include endpoints

None

26472

6. Filter based on genotype QC (FinnGen only)

25620

Control definitions (FinnGen only)

Control exclude J10_UPPERINFEC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J00-J06
Name in latin Sinuitis acuta

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 246100 116994 127821
Only index persons 222657 106627 116030
Unadjusted period prevalence (%)
Whole population 3.45 3.35 3.57
Only index persons 4.19 3.92 4.43
Median age at first event (years)
Whole population 28.88 37.98 20.35
Only index persons 27.83 36.15 20.18

-FinnGen-

Key figures

All Female Male
Number of individuals 25620 15131 10489
Unadjusted period prevalence (%) 5.67 5.94 5.27
Median age at first event (years) 33.76 38.63 26.74

-FinRegistry-

Age distribution of first events

01020304050607080900k5k10k15k20k25k30k35k40k45kAgeIndividuals

-FinnGen-

Age distribution of first events

01020304050607080900.0k0.5k1.0k1.5k2.0k2.5k3.0k3.5k4.0kAgeIndividuals

-FinRegistry-

Year distribution of first events

1970197519801985199019952000200520102015202020220k5k10k15k20k25k30kYearIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952000200520102015202020230.0k0.5k1.0k1.5k2.0k2.5k3.0k3.5k4.0kYearIndividuals

-FinRegistry-

Cumulative Incidence Function

010203040506070809010001234567891011AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000246810121416AgeProbability of first incidence (%)

Mortality – FinRegistry

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Association

Association between endpoint J10_SINUSITIS and mortality.

Females

Parameter HR [95% CI] p-value
J10_SINUSITIS 1.39 [1.28, 1.51] < 0.001
Birth year 0.997 [0.99, 1.01] 0.509

During the follow-up period (1.1.1998 — 31.12.2019), 8951 out of 80536 females with J10_SINUSITIS died.

Males

Parameter HR [95% CI] p-value
J10_SINUSITIS 1.609 [1.47, 1.76] < 0.001
Birth year 0.986 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 8197 out of 62147 males with J10_SINUSITIS died.

Mortality risk

Mortality risk for people of age

years, who have J10_SINUSITIS.

N-year risk Females Males
1 0.174% 0.373%
5 0.875% 1.645%
10 2.12% 4.408%
15 3.965% 8.101%
20 7.36% 13.499%

Relationships between endpoints

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Index endpoint: J10_SINUSITIS – Acute sinusitis

GWS hits: 7

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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