pasteurellosis: Infections with bacteria of the genus pasteurella.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
150478 |
6. Filter based on genotype QC (FinnGen only) |
144808 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF2
COPD/asthma/ILD related infections
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2053597 | 887115 | 1149809 |
| Only index persons | 1568301 | 681421 | 886880 |
| Unadjusted period prevalence (%) | |||
| Whole population | 29.10 | 25.41 | 32.13 |
| Only index persons | 30.03 | 25.05 | 33.86 |
| Median age at first event (years) | |||
| Whole population | 30.48 | 42.53 | 20.63 |
| Only index persons | 29.05 | 40.23 | 20.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 144808 | 67880 | 76928 |
| Unadjusted period prevalence (%) | 33.02 | 26.66 | 38.63 |
| Median age at first event (years) | 42.98 | 43.04 | 42.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint PULM_INFECTIONS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PULM_INFECTIONS | 2.696 [2.5, 2.91] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 127782 out of 600825 females with PULM_INFECTIONS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PULM_INFECTIONS | 3.237 [2.98, 3.52] | < 0.001 |
| Birth year | 0.978 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 139881 out of 608631 males with PULM_INFECTIONS died.
Mortality risk
Mortality risk for people of age
years, who have PULM_INFECTIONS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.286% |
| 5 | 0.961% | 1.828% |
| 10 | 2.17% | 4.524% |
| 15 | 4.088% | 8.177% |
| 20 | 7.123% | 13.01% |
Relationships between endpoints
↥Index endpoint: PULM_INFECTIONS – COPD/asthma/ILD related infections
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data