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Acute upper respiratory infections of multiple and unspecified sites

EFO MESH Endpoint Browser PheWeb

J10_ACUTEUPPERINFEC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J06
  • Hospital discharge: ICD-9 — 465
  • Hospital discharge: ICD-8 — 465
  • Cause of death: ICD-10 — J06
  • Cause of death: ICD-9 — 465
  • Cause of death: ICD-8 — 465

2 out of 7 registries used, show all original rules.

48371

4. Check minimum number of events

None

48371

5. Include endpoints

None

48371

6. Filter based on genotype QC (FinnGen only)

46442

Control definitions (FinnGen only)

Control exclude J10_UPPERINFEC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J00-J06
Name in latin Infectiones acutae respiratoriae superiores locis multis sive non specificatis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 711363 291014 417375
Only index persons 538991 213493 325498
Unadjusted period prevalence (%)
Whole population 10.26 8.34 11.66
Only index persons 10.61 7.85 12.43
Median age at first event (years)
Whole population 19.92 20.17 19.59
Only index persons 23.40 28.66 19.95

-FinnGen-

Key figures

All Female Male
Number of individuals 46442 21959 24483
Unadjusted period prevalence (%) 10.56 8.62 12.30
Median age at first event (years) 29.19 38.78 20.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint J10_ACUTEUPPERINFEC and mortality.

Females

Parameter HR [95% CI] p-value
J10_ACUTEUPPERINFEC 1.789 [1.6, 1.99] < 0.001
Birth year 0.994 [0.99, 1.0] 0.11

During the follow-up period (1.1.1998 — 31.12.2019), 24129 out of 214161 females with J10_ACUTEUPPERINFEC died.

Males

Parameter HR [95% CI] p-value
J10_ACUTEUPPERINFEC 2.088 [1.84, 2.37] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 20954 out of 219885 males with J10_ACUTEUPPERINFEC died.

Mortality risk

Mortality risk for people of age

years, who have J10_ACUTEUPPERINFEC.

N-year risk Females Males
1 0.107% 0.356%
5 0.846% 1.998%
10 2.163% 5.163%
15 4.258% 9.611%
20 7.621% 15.706%

Relationships between endpoints

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Index endpoint: J10_ACUTEUPPERINFEC – Acute upper respiratory infections of multiple and unspecified sites

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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