bronchitis: An acute or chronic inflammatory process affecting the bronchi. [database_cross_reference: NCIT:C2911]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
71940 |
6. Filter based on genotype QC (FinnGen only) |
69104 |
Control definitions (FinnGen only)
Control exclude
J10_LOWERINF
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Bronchitis
based on the number of shared cases.
Similar with more cases:
- Asthma/COPD-related acute respiratory infections
- COPD/asthma/ILD related infections
- COPD/asthma related infections
- Diseases of the respiratory system
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1062108 | 444809 | 611677 |
| Only index persons | 805698 | 331787 | 473911 |
| Unadjusted period prevalence (%) | |||
| Whole population | 15.21 | 12.74 | 17.09 |
| Only index persons | 15.66 | 12.20 | 18.09 |
| Median age at first event (years) | |||
| Whole population | 23.42 | 28.02 | 19.73 |
| Only index persons | 25.77 | 34.03 | 19.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 69104 | 32489 | 36615 |
| Unadjusted period prevalence (%) | 15.74 | 12.76 | 18.39 |
| Median age at first event (years) | 31.63 | 42.97 | 21.57 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint BRONCHITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| BRONCHITIS | 1.991 [1.82, 2.18] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.206 |
During the follow-up period (1.1.1998 — 31.12.2019), 54911 out of 326628 females with BRONCHITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| BRONCHITIS | 2.278 [2.05, 2.53] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 52805 out of 344476 males with BRONCHITIS died.
Mortality risk
Mortality risk for people of age
years, who have BRONCHITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.162% | 0.347% |
| 5 | 1.036% | 2.185% |
| 10 | 2.572% | 5.546% |
| 15 | 4.885% | 10.675% |
| 20 | 8.587% | 17.253% |
Relationships between endpoints
↥Index endpoint: BRONCHITIS – Bronchitis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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