bronchitis: An acute or chronic inflammatory process affecting the bronchi. [database_cross_reference: NCIT:C2911]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
22186 |
4. Check minimum number of eventsNone |
22186 |
5. Include endpoints |
26481 |
6. Filter based on genotype QC (FinnGen only) |
25422 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other acute lower respiratory infections
based on the number of shared cases.
Similar with more cases:
- Bronchitis
- Asthma/COPD-related acute respiratory infections
- COPD/asthma/ILD related infections
- COPD/asthma related infections
- Diseases of the respiratory system
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 403846 | 178438 | 222719 |
| Only index persons | 295572 | 133385 | 162187 |
| Unadjusted period prevalence (%) | |||
| Whole population | 5.71 | 5.11 | 6.22 |
| Only index persons | 5.61 | 4.90 | 6.19 |
| Median age at first event (years) | |||
| Whole population | 31.86 | 46.58 | 19.58 |
| Only index persons | 32.44 | 47.63 | 19.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 25422 | 12407 | 13015 |
| Unadjusted period prevalence (%) | 5.72 | 4.87 | 6.54 |
| Median age at first event (years) | 55.34 | 51.60 | 58.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_LOWERINF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_LOWERINF | 2.119 [1.92, 2.34] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 36159 out of 138482 females with J10_LOWERINF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_LOWERINF | 2.534 [2.26, 2.84] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 36311 out of 154283 males with J10_LOWERINF died.
Mortality risk
Mortality risk for people of age
years, who have J10_LOWERINF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.156% | 0.414% |
| 5 | 1.052% | 2.613% |
| 10 | 2.428% | 6.467% |
| 15 | 4.254% | 11.723% |
| 20 | 7.135% | 19.247% |
Relationships between endpoints
↥Index endpoint: J10_LOWERINF – Other acute lower respiratory infections
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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