No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2690 |
4. Check minimum number of eventsNone |
2690 |
5. Include endpointsNone |
2690 |
6. Filter based on genotype QC (FinnGen only) |
2533 |
Control definitions (FinnGen only)
Control exclude
J10_LOWERINF
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J20-J22
Name in latin
Bronchiolitis acuta
Similar endpoints
↥List of similar endpoints to
Acute bronchiolitis
based on the number of shared cases.
Similar with more cases:
- Other acute lower respiratory infections
- Bronchitis
- Asthma/COPD-related acute respiratory infections
- COPD/asthma/ILD related infections
- COPD/asthma related infections
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 125428 | 48749 | 76593 |
| Only index persons | 76962 | 29799 | 47163 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.85 | 1.40 | 2.14 |
| Only index persons | 1.53 | 1.10 | 1.80 |
| Median age at first event (years) | |||
| Whole population | 1.09 | 1.04 | 1.04 |
| Only index persons | 1.08 | 1.11 | 1.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2533 | 1337 | 1196 |
| Unadjusted period prevalence (%) | 0.56 | 0.53 | 0.60 |
| Median age at first event (years) | 1.55 | 1.59 | 1.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_BRONCHIOLITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_BRONCHIOLITIS | 2.308 [1.87, 2.84] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.057 |
During the follow-up period (1.1.1998 — 31.12.2019), 1374 out of 42105 females with J10_BRONCHIOLITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_BRONCHIOLITIS | 2.394 [1.83, 3.13] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 1410 out of 66255 males with J10_BRONCHIOLITIS died.
Mortality risk
Mortality risk for people of age
years, who have J10_BRONCHIOLITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.33% |
| 5 | 1.194% | 2.613% |
| 10 | 3.184% | 6.478% |
| 15 | 5.797% | 12.763% |
| 20 | 9.852% | 21.322% |
Relationships between endpoints
↥Index endpoint: J10_BRONCHIOLITIS – Acute bronchiolitis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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