pneumonia: An acute, acute and chronic, or chronic inflammation focally or diffusely affecting the lung parenchyma, caused by an infection in one or both of the lungs (by bacteria, viruses, fungi, or mycoplasma.). Symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
5916 |
4. Check minimum number of eventsNone |
5916 |
5. Include endpointsNone |
5916 |
6. Filter based on genotype QC (FinnGen only) |
5713 |
Control definitions (FinnGen only)
Control exclude
J10_LOWERINF
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J20-J22
Name in latin
Infectio respiratoria inferior acuta non specificata
Similar endpoints
↥List of similar endpoints to
Unspecified acute lower respiratory infection
based on the number of shared cases.
Similar with more cases:
- Other acute lower respiratory infections
- Bronchitis
- Asthma/COPD-related acute respiratory infections
- COPD/asthma/ILD related infections
- COPD/asthma related infections
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 70784 | 28053 | 42315 |
| Only index persons | 58725 | 22829 | 35896 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.03 | 0.80 | 1.18 |
| Only index persons | 1.16 | 0.84 | 1.37 |
| Median age at first event (years) | |||
| Whole population | 33.27 | 52.55 | 20.18 |
| Only index persons | 29.85 | 45.27 | 20.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5713 | 2321 | 3392 |
| Unadjusted period prevalence (%) | 1.38 | 0.91 | 1.70 |
| Median age at first event (years) | 30.93 | 44.97 | 21.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_ACUTELOWERNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ACUTELOWERNAS | 2.522 [2.2, 2.9] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.044 |
During the follow-up period (1.1.1998 — 31.12.2019), 5097 out of 15402 females with J10_ACUTELOWERNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ACUTELOWERNAS | 2.888 [2.44, 3.42] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.022 |
During the follow-up period (1.1.1998 — 31.12.2019), 5409 out of 15571 males with J10_ACUTELOWERNAS died.
Mortality risk
Mortality risk for people of age
years, who have J10_ACUTELOWERNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.221% | 0.55% |
| 5 | 1.399% | 3.759% |
| 10 | 3.403% | 8.868% |
| 15 | 5.952% | 16.599% |
| 20 | 10.755% | 27.09% |
Relationships between endpoints
↥Index endpoint: J10_ACUTELOWERNAS – Unspecified acute lower respiratory infection
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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