Acute bronchitis

J10_BRONCHITIS

bronchitis: An acute or chronic inflammatory process affecting the bronchi. [database_cross_reference: NCIT:C2911]

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 J20
  • Hospital discharge: ICD-9 4660
  • Cause of death: ICD-10 J20
  • Cause of death: ICD-9 4660

2 out of 7 registries used, show all original rules.

19270

4. Check minimum number of events

None

19270

5. Include endpoints

None

19270

6. Filter based on genotype QC (FinnGen only)

18508

Control definitions (FinnGen only)

Control exclude J10_LOWERINF

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J20-J22
Name in latin Bronchitis acuta

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 235107 113072 119750
Only index persons 179229 89062 90167
Unadjusted period prevalence (%)
Whole population 3.28 3.24 3.35
Only index persons 3.36 3.27 3.44
Median age at first event (years)
Whole population 60.13 65.06 55.23
Only index persons 55.16 61.36 49.03

-FinnGen-

Key figures

All Female Male
Number of individuals 18508 9435 9073
Unadjusted period prevalence (%) 4.12 3.71 4.56
Median age at first event (years) 60.47 55.75 65.37

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint J10_BRONCHITIS and mortality.

Females

Parameter HR [95% CI] p-value
J10_BRONCHITIS 1.998 [1.81, 2.2] < 0.001
Birth year 0.992 [0.98, 1.0] 0.046

During the follow-up period (1.1.1998 — 31.12.2019), 31821 out of 90646 females with J10_BRONCHITIS died.

Males

Parameter HR [95% CI] p-value
J10_BRONCHITIS 2.44 [2.18, 2.73] < 0.001
Birth year 0.989 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 31790 out of 86134 males with J10_BRONCHITIS died.

Mortality risk

Mortality risk for people of age

years, who have J10_BRONCHITIS.

N-year risk Females Males
1 0.097% 0.458%
5 1.058% 2.676%
10 2.47% 6.728%
15 4.648% 12.352%
20 7.839% 20.384%

Relationships between endpoints

Index endpoint: J10_BRONCHITIS – Acute bronchitis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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