bronchitis: An acute or chronic inflammatory process affecting the bronchi. [database_cross_reference: NCIT:C2911]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
19270 |
4. Check minimum number of eventsNone |
19270 |
5. Include endpointsNone |
19270 |
6. Filter based on genotype QC (FinnGen only) |
18508 |
Control definitions (FinnGen only)
Control exclude
J10_LOWERINF
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J20-J22
Name in latin
Bronchitis acuta
Similar endpoints
↥List of similar endpoints to
Acute bronchitis
based on the number of shared cases.
Similar with more cases:
- Other acute lower respiratory infections
- Bronchitis
- Asthma/COPD-related acute respiratory infections
- COPD/asthma/ILD related infections
- COPD/asthma related infections
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 235107 | 113072 | 119750 |
| Only index persons | 179229 | 89062 | 90167 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.28 | 3.24 | 3.35 |
| Only index persons | 3.36 | 3.27 | 3.44 |
| Median age at first event (years) | |||
| Whole population | 60.13 | 65.06 | 55.23 |
| Only index persons | 55.16 | 61.36 | 49.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 18508 | 9435 | 9073 |
| Unadjusted period prevalence (%) | 4.12 | 3.71 | 4.56 |
| Median age at first event (years) | 60.47 | 55.75 | 65.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_BRONCHITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_BRONCHITIS | 1.998 [1.81, 2.2] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.046 |
During the follow-up period (1.1.1998 — 31.12.2019), 31821 out of 90646 females with J10_BRONCHITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_BRONCHITIS | 2.44 [2.18, 2.73] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 31790 out of 86134 males with J10_BRONCHITIS died.
Mortality risk
Mortality risk for people of age
years, who have J10_BRONCHITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.458% |
| 5 | 1.058% | 2.676% |
| 10 | 2.47% | 6.728% |
| 15 | 4.648% | 12.352% |
| 20 | 7.839% | 20.384% |
Relationships between endpoints
↥Index endpoint: J10_BRONCHITIS – Acute bronchitis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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