common cold: An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
5069 |
4. Check minimum number of eventsNone |
5069 |
5. Include endpointsNone |
5069 |
6. Filter based on genotype QC (FinnGen only) |
4925 |
Control definitions (FinnGen only)
Control exclude
J10_UPPERINFEC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J00-J06
Name in latin
Nasopharyngitis acuta
Similar endpoints
↥List of similar endpoints to
Acute nasopharyngitis (common cold)
based on the number of shared cases.
Similar with more cases:
- Acute upper respiratory infections
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 65629 | 15921 | 49486 |
| Only index persons | 56960 | 12411 | 44549 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.15 | 0.46 | 1.38 |
| Only index persons | 1.43 | 0.46 | 1.70 |
| Median age at first event (years) | |||
| Whole population | 20.93 | 23.74 | 19.98 |
| Only index persons | 20.79 | 23.64 | 20.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4925 | 1410 | 3515 |
| Unadjusted period prevalence (%) | 1.42 | 0.55 | 1.77 |
| Median age at first event (years) | 22.01 | 26.66 | 20.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_COLD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_COLD | 1.352 [1.14, 1.6] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.058 |
During the follow-up period (1.1.1998 — 31.12.2019), 412 out of 6605 females with J10_COLD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_COLD | 1.28 [1.1, 1.49] | 0.002 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 409 out of 10441 males with J10_COLD died.
Mortality risk
Mortality risk for people of age
years, who have J10_COLD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.135% | 0.228% |
| 5 | 0.655% | 1.443% |
| 10 | 1.724% | 3.817% |
| 15 | 3.26% | 7.192% |
| 20 | 5.693% | 11.954% |
Relationships between endpoints
↥Index endpoint: J10_COLD – Acute nasopharyngitis (common cold)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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