≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Acute laryngitis and tracheitis

DOID EFO Endpoint Browser PheWeb

J10_LARYNGITIS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J04, J05.0
  • Hospital discharge: ICD-9 — 464
  • Hospital discharge: ICD-8 — 464|50803
  • Hospital discharge: excluded ICD-9 — 4643
  • Hospital discharge: excluded ICD-8 — 46404
  • Cause of death: ICD-10 — J04, J05.0
  • Cause of death: ICD-9 — 464
  • Cause of death: ICD-8 — 464|50803
  • Cause of death: excluded ICD-9 — 4643
  • Cause of death: excluded ICD-8 — 46404

2 out of 7 registries used, show all original rules.

5579

4. Check minimum number of events

None

5579

5. Include endpoints

None

5579

6. Filter based on genotype QC (FinnGen only)

5370

Control definitions (FinnGen only)

Control exclude J10_UPPERINFEC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 128212 46953 81099
Only index persons 93013 34477 58536
Unadjusted period prevalence (%)
Whole population 1.93 1.34 2.27
Only index persons 1.88 1.27 2.23
Median age at first event (years)
Whole population 2.45 2.67 2.25
Only index persons 2.67 3.09 2.42

-FinnGen-

Key figures

All Female Male
Number of individuals 5370 2968 2402
Unadjusted period prevalence (%) 1.18 1.17 1.21
Median age at first event (years) 4.86 5.86 3.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint J10_LARYNGITIS and mortality.

Females

Parameter HR [95% CI] p-value
J10_LARYNGITIS 1.413 [1.2, 1.67] < 0.001
Birth year 0.993 [0.98, 1.0] 0.13

During the follow-up period (1.1.1998 — 31.12.2019), 969 out of 30916 females with J10_LARYNGITIS died.

Males

Parameter HR [95% CI] p-value
J10_LARYNGITIS 1.41 [1.07, 1.87] 0.016
Birth year 0.989 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 775 out of 49448 males with J10_LARYNGITIS died.

Mortality risk

Mortality risk for people of age

years, who have J10_LARYNGITIS.

N-year risk Females Males
1 0.139% 0.318%
5 0.796% 1.811%
10 1.901% 4.347%
15 3.684% 8.009%
20 6.57% 13.725%

Relationships between endpoints

↥

Index endpoint: J10_LARYNGITIS – Acute laryngitis and tracheitis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data