pneumonia: An acute, acute and chronic, or chronic inflammation focally or diffusely affecting the lung parenchyma, caused by an infection in one or both of the lungs (by bacteria, viruses, fungi, or mycoplasma.). Symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
72852 |
6. Filter based on genotype QC (FinnGen only) |
70150 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
All pneumoniae
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 933507 | 416509 | 505100 |
| Only index persons | 672116 | 309908 | 362208 |
| Unadjusted period prevalence (%) | |||
| Whole population | 13.12 | 11.93 | 14.11 |
| Only index persons | 12.70 | 11.39 | 13.83 |
| Median age at first event (years) | |||
| Whole population | 66.85 | 69.93 | 64.17 |
| Only index persons | 61.88 | 65.24 | 59.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 70150 | 29429 | 40721 |
| Unadjusted period prevalence (%) | 16.72 | 11.56 | 20.45 |
| Median age at first event (years) | 62.80 | 56.79 | 67.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_PNEUMONIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PNEUMONIA | 3.156 [2.89, 3.44] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 102583 out of 257090 females with J10_PNEUMONIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PNEUMONIA | 3.745 [3.42, 4.1] | < 0.001 |
| Birth year | 0.976 [0.97, 0.98] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 122367 out of 287591 males with J10_PNEUMONIA died.
Mortality risk
Mortality risk for people of age
years, who have J10_PNEUMONIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.14% | 0.313% |
| 5 | 0.95% | 1.903% |
| 10 | 2.557% | 4.628% |
| 15 | 4.8% | 8.545% |
| 20 | 7.905% | 14.113% |
Relationships between endpoints
↥Index endpoint: J10_PNEUMONIA – All pneumoniae
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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