bacterial pneumonia: Inflammation of the lung parenchyma that is caused by bacterial infections.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
101 |
4. Check minimum number of eventsNone |
101 |
5. Include endpointsNone |
101 |
6. Filter based on genotype QC (FinnGen only) |
100 |
Control definitions (FinnGen only)
Control exclude
J10_INFLUPNEU
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J09-J18
Name in latin
Pneumonia ab Haemophilo influenzae
Similar endpoints
↥List of similar endpoints to
Pneumonia due to Haemophilus influenzae
based on the number of shared cases.
Similar with more cases:
- Bacterial pneumoniae
- Bacterial pneumonia (organism specified)
- Pneumonia (excl. viral and due to other infectious organisms not elsewhere classified)
- Pneumonias (Asthma/COPD co-morbidities)
- COPD/asthma/ILD related pneumonia or pneumonia derived septicaemia
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1201 | 473 | 712 |
| Only index persons | 836 | 381 | 455 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 50.62 | 48.81 | 51.68 |
| Only index persons | 32.44 | 41.55 | 24.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 100 | 49 | 51 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 46.90 | 40.48 | 53.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint J10_PNEUMOHAEM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PNEUMOHAEM | 2.174 [1.13, 4.17] | 0.019 |
| Birth year | 1.002 [0.99, 1.01] | 0.643 |
During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 195 females with J10_PNEUMOHAEM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PNEUMOHAEM | 3.488 [2.05, 5.92] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 208 males with J10_PNEUMOHAEM died.
Mortality risk
Mortality risk for people of age
years, who have J10_PNEUMOHAEM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.25% | 0.782% |
| 5 | 1.35% | 3.822% |
| 10 | 3.604% | 9.348% |
| 15 | 7.552% | 17.25% |
| 20 | 13.386% | 27.418% |
Relationships between endpoints
↥Index endpoint: J10_PNEUMOHAEM – Pneumonia due to Haemophilus influenzae
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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