Pneumonia due to Haemophilus influenzae

J10_PNEUMOHAEM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 J14
  • Hospital discharge: ICD-9 4822
  • Hospital discharge: ICD-8 48210
  • Cause of death: ICD-10 J14
  • Cause of death: ICD-9 4822
  • Cause of death: ICD-8 48210

2 out of 7 registries used, show all original rules.

101

4. Check minimum number of events

None

101

5. Include endpoints

None

101

6. Filter based on genotype QC (FinnGen only)

100

Control definitions (FinnGen only)

Control exclude J10_INFLUPNEU

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 J09-J18
Name in latin Pneumonia ab Haemophilo influenzae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1201 473 712
Only index persons 836 381 455
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.02 0.01 0.02
Median age at first event (years)
Whole population 50.62 48.81 51.68
Only index persons 32.44 41.55 24.81

-FinnGen-

Key figures

All Female Male
Number of individuals 100 49 51
Unadjusted period prevalence (%) 0.02 0.02 0.03
Median age at first event (years) 46.90 40.48 53.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint J10_PNEUMOHAEM and mortality.

Females

Parameter HR [95% CI] p-value
J10_PNEUMOHAEM 2.174 [1.13, 4.17] 0.019
Birth year 1.002 [0.99, 1.01] 0.643

During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 195 females with J10_PNEUMOHAEM died.

Males

Parameter HR [95% CI] p-value
J10_PNEUMOHAEM 3.488 [2.05, 5.92] < 0.001
Birth year 0.985 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 208 males with J10_PNEUMOHAEM died.

Mortality risk

Mortality risk for people of age

years, who have J10_PNEUMOHAEM.

N-year risk Females Males
1 0.25% 0.782%
5 1.35% 3.822%
10 3.604% 9.348%
15 7.552% 17.25%
20 13.386% 27.418%

Relationships between endpoints

Index endpoint: J10_PNEUMOHAEM – Pneumonia due to Haemophilus influenzae

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data