No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
68858 |
4. Check minimum number of eventsNone |
68858 |
5. Include endpoints |
78367 |
6. Filter based on genotype QC (FinnGen only) |
75441 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Influenza and pneumonia
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1010197 | 448995 | 548933 |
| Only index persons | 735933 | 336508 | 399425 |
| Unadjusted period prevalence (%) | |||
| Whole population | 14.21 | 12.86 | 15.34 |
| Only index persons | 13.93 | 12.37 | 15.25 |
| Median age at first event (years) | |||
| Whole population | 64.90 | 68.38 | 61.89 |
| Only index persons | 59.27 | 63.59 | 55.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 75441 | 31921 | 43520 |
| Unadjusted period prevalence (%) | 17.91 | 12.54 | 21.86 |
| Median age at first event (years) | 61.92 | 56.11 | 66.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_INFLUPNEU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_INFLUPNEU | 3.184 [2.93, 3.47] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 104721 out of 278871 females with J10_INFLUPNEU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_INFLUPNEU | 3.736 [3.41, 4.09] | < 0.001 |
| Birth year | 0.976 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 123947 out of 312398 males with J10_INFLUPNEU died.
Mortality risk
Mortality risk for people of age
years, who have J10_INFLUPNEU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.146% | 0.285% |
| 5 | 0.923% | 1.81% |
| 10 | 2.341% | 4.455% |
| 15 | 4.229% | 8.324% |
| 20 | 7.082% | 13.754% |
Relationships between endpoints
↥Index endpoint: J10_INFLUPNEU – Influenza and pneumonia
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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