influenza: An acute viral infection of the respiratory tract, occurring in isolated cases, in epidemics, or in pandemics; it is caused by serologically different strains of viruses (influenzaviruses) designated A, B, and C, has a 3-day incubation period, and usually lasts for 3 to 10 days. It is marked by inflammation of the nasal mucosa, pharynx, and conjunctiva; headache; myalgia; often fever, chills, and prostration; and occasionally involvement of the myocardium or central nervous system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
10564 |
4. Check minimum number of eventsNone |
10564 |
5. Include endpointsNone |
10564 |
6. Filter based on genotype QC (FinnGen only) |
10134 |
Control definitions (FinnGen only)
Control exclude
J10_INFLUPNEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
All influenza
based on the number of shared cases.
Similar with more cases:
- Influenza and pneumonia
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 126708 | 55538 | 70517 |
| Only index persons | 106944 | 46476 | 60468 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.80 | 1.59 | 1.97 |
| Only index persons | 2.05 | 1.71 | 2.31 |
| Median age at first event (years) | |||
| Whole population | 36.68 | 54.64 | 22.36 |
| Only index persons | 36.71 | 54.53 | 23.02 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10134 | 4622 | 5512 |
| Unadjusted period prevalence (%) | 2.33 | 1.82 | 2.77 |
| Median age at first event (years) | 54.22 | 55.30 | 53.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_INFLUENZA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_INFLUENZA | 1.817 [1.58, 2.09] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.059 |
During the follow-up period (1.1.1998 — 31.12.2019), 7464 out of 39837 females with J10_INFLUENZA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_INFLUENZA | 2.08 [1.77, 2.45] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.042 |
During the follow-up period (1.1.1998 — 31.12.2019), 7353 out of 45296 males with J10_INFLUENZA died.
Mortality risk
Mortality risk for people of age
years, who have J10_INFLUENZA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.156% | 0.399% |
| 5 | 0.826% | 2.446% |
| 10 | 2.188% | 6.453% |
| 15 | 4.45% | 12.412% |
| 20 | 7.925% | 19.88% |
Relationships between endpoints
↥Index endpoint: J10_INFLUENZA – All influenza
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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