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Pneumonia due to other infectious organisms, not elsewhere classified

DOID EFO Endpoint Browser PheWeb

J10_PNEUMONONBACT

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J16|J17[2-8]
  • Hospital discharge: ICD-9 — 483
  • Hospital discharge: ICD-8 — 48399
  • Cause of death: ICD-10 — J16|J17[2-8]
  • Cause of death: ICD-9 — 483
  • Cause of death: ICD-8 — 48399

2 out of 7 registries used, show all original rules.

1058

4. Check minimum number of events

None

1058

5. Include endpoints

None

1058

6. Filter based on genotype QC (FinnGen only)

1030

Control definitions (FinnGen only)

Control exclude J10_INFLUPNEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9869 4313 5437
Only index persons 7295 3334 3961
Unadjusted period prevalence (%)
Whole population 0.14 0.12 0.15
Only index persons 0.14 0.12 0.15
Median age at first event (years)
Whole population 55.32 52.82 57.02
Only index persons 43.09 42.06 43.96

-FinnGen-

Key figures

All Female Male
Number of individuals 1030 493 537
Unadjusted period prevalence (%) 0.23 0.19 0.27
Median age at first event (years) 55.04 47.26 62.18

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint J10_PNEUMONONBACT and mortality.

Females

Parameter HR [95% CI] p-value
J10_PNEUMONONBACT 3.241 [2.53, 4.15] < 0.001
Birth year 0.999 [0.99, 1.01] 0.776

During the follow-up period (1.1.1998 — 31.12.2019), 589 out of 1540 females with J10_PNEUMONONBACT died.

Males

Parameter HR [95% CI] p-value
J10_PNEUMONONBACT 3.747 [2.93, 4.8] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 889 out of 1940 males with J10_PNEUMONONBACT died.

Mortality risk

Mortality risk for people of age

years, who have J10_PNEUMONONBACT.

N-year risk Females Males
1 0.373% 0.717%
5 2.086% 3.691%
10 5.952% 9.123%
15 10.65% 17.786%
20 18.24% 28.582%

Relationships between endpoints

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Index endpoint: J10_PNEUMONONBACT – Pneumonia due to other infectious organisms, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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