bacterial pneumonia: Inflammation of the lung parenchyma that is caused by bacterial infections.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
20000 |
6. Filter based on genotype QC (FinnGen only) |
19249 |
Control definitions (FinnGen only)
Control exclude
J10_INFLUPNEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Bacterial pneumoniae
based on the number of shared cases.
Similar with more cases:
- Bacterial pneumonia (organism specified)
- Pneumonia (excl. viral and due to other infectious organisms not elsewhere classified)
- Pneumonias (Asthma/COPD co-morbidities)
- COPD/asthma/ILD related pneumonia or pneumonia derived septicaemia
- COPD/asthma related pneumonia or pneumonia derived septicaemia
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 247249 | 106677 | 136841 |
| Only index persons | 171910 | 78235 | 93675 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.49 | 3.06 | 3.82 |
| Only index persons | 3.26 | 2.88 | 3.58 |
| Median age at first event (years) | |||
| Whole population | 67.06 | 68.45 | 65.77 |
| Only index persons | 60.69 | 62.02 | 59.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 19249 | 7905 | 11344 |
| Unadjusted period prevalence (%) | 4.63 | 3.10 | 5.70 |
| Median age at first event (years) | 62.65 | 55.57 | 67.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_PNEUMOBACT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PNEUMOBACT | 2.605 [2.38, 2.86] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.219 |
During the follow-up period (1.1.1998 — 31.12.2019), 32555 out of 75755 females with J10_PNEUMOBACT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PNEUMOBACT | 3.073 [2.78, 3.4] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 44972 out of 92192 males with J10_PNEUMOBACT died.
Mortality risk
Mortality risk for people of age
years, who have J10_PNEUMOBACT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.189% | 0.516% |
| 5 | 1.317% | 3.084% |
| 10 | 3.359% | 7.779% |
| 15 | 6.726% | 14.262% |
| 20 | 11.588% | 23.515% |
Relationships between endpoints
↥Index endpoint: J10_PNEUMOBACT – Bacterial pneumoniae
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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