corneal neovascularization: New blood vessels originating from the corneal veins and extending from the limbus into the adjacent corneal stroma. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as trachoma, viral interstitial keratitis, microbial keratoconjunctivitis, and the immune response elicited by corneal transplantation.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
24386 |
4. Check minimum number of eventsNone |
24386 |
5. Include endpoints |
25317 |
6. Filter based on genotype QC (FinnGen only) |
24337 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Disorders of sclera, cornea, iris and ciliary body
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 230055 | 113677 | 115074 |
| Only index persons | 211242 | 105198 | 106044 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.22 | 3.26 | 3.22 |
| Only index persons | 3.96 | 3.87 | 4.05 |
| Median age at first event (years) | |||
| Whole population | 46.12 | 49.90 | 42.42 |
| Only index persons | 45.36 | 48.92 | 41.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 24337 | 13719 | 10618 |
| Unadjusted period prevalence (%) | 5.36 | 5.39 | 5.33 |
| Median age at first event (years) | 49.91 | 49.09 | 50.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_SCLERACORNEA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_SCLERACORNEA | 1.118 [1.02, 1.22] | 0.012 |
| Birth year | 0.993 [0.99, 1.0] | 0.107 |
During the follow-up period (1.1.1998 — 31.12.2019), 12312 out of 92135 females with H7_SCLERACORNEA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_SCLERACORNEA | 1.124 [1.02, 1.23] | 0.014 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 11272 out of 92365 males with H7_SCLERACORNEA died.
Mortality risk
Mortality risk for people of age
years, who have H7_SCLERACORNEA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.094% | 0.216% |
| 5 | 0.589% | 1.306% |
| 10 | 1.511% | 3.292% |
| 15 | 3.045% | 6.42% |
| 20 | 5.352% | 11.015% |
Relationships between endpoints
↥Index endpoint: H7_SCLERACORNEA – Disorders of sclera, cornea, iris and ciliary body
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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