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Corneal ulcer

DOID EFO Endpoint Browser PheWeb

H7_CORNULCER

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H16.0
  • Hospital discharge: ICD-9 — 3700
  • Hospital discharge: ICD-8 — 36300
  • Cause of death: ICD-10 — H16.0
  • Cause of death: ICD-9 — 3700
  • Cause of death: ICD-8 — 36300

2 out of 7 registries used, show all original rules.

7321

4. Check minimum number of events

None

7321

5. Include endpoints

None

7321

6. Filter based on genotype QC (FinnGen only)

7048

Control definitions (FinnGen only)

Control exclude H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H16
Name in latin Ulcus corneae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 71837 31929 39537
Only index persons 66328 29586 36742
Unadjusted period prevalence (%)
Whole population 1.02 0.91 1.10
Only index persons 1.26 1.09 1.40
Median age at first event (years)
Whole population 43.74 47.62 40.66
Only index persons 43.66 47.28 40.74

-FinnGen-

Key figures

All Female Male
Number of individuals 7048 3749 3299
Unadjusted period prevalence (%) 1.56 1.47 1.66
Median age at first event (years) 49.45 48.72 50.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_CORNULCER and mortality.

Females

Parameter HR [95% CI] p-value
H7_CORNULCER 1.234 [1.12, 1.36] < 0.001
Birth year 0.996 [0.99, 1.0] 0.371

During the follow-up period (1.1.1998 — 31.12.2019), 3632 out of 26817 females with H7_CORNULCER died.

Males

Parameter HR [95% CI] p-value
H7_CORNULCER 1.201 [1.09, 1.33] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 3576 out of 33446 males with H7_CORNULCER died.

Mortality risk

Mortality risk for people of age

years, who have H7_CORNULCER.

N-year risk Females Males
1 0.102% 0.213%
5 0.589% 1.361%
10 1.836% 3.318%
15 3.678% 6.174%
20 6.287% 10.391%

Relationships between endpoints

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Index endpoint: H7_CORNULCER – Corneal ulcer

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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