keratitis: Inflammation of the cornea. [ NCIT:P378 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
14969 |
4. Check minimum number of eventsNone |
14969 |
5. Include endpoints |
15330 |
6. Filter based on genotype QC (FinnGen only) |
14741 |
Control definitions (FinnGen only)
Control exclude
H7_SCLERACORNEA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Keratitis
based on the number of shared cases.
Similar with more cases:
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 145316 | 69662 | 74881 |
| Only index persons | 134275 | 64730 | 69545 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.04 | 2.00 | 2.09 |
| Only index persons | 2.52 | 2.38 | 2.65 |
| Median age at first event (years) | |||
| Whole population | 45.54 | 49.92 | 41.52 |
| Only index persons | 44.97 | 49.04 | 41.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 14741 | 8188 | 6553 |
| Unadjusted period prevalence (%) | 3.25 | 3.22 | 3.29 |
| Median age at first event (years) | 50.70 | 49.98 | 51.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_KERATITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_KERATITIS | 1.181 [1.08, 1.29] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.134 |
During the follow-up period (1.1.1998 — 31.12.2019), 8153 out of 57884 females with H7_KERATITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_KERATITIS | 1.196 [1.09, 1.31] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 7325 out of 62305 males with H7_KERATITIS died.
Mortality risk
Mortality risk for people of age
years, who have H7_KERATITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.128% | 0.265% |
| 5 | 0.735% | 1.489% |
| 10 | 1.656% | 3.479% |
| 15 | 3.098% | 6.544% |
| 20 | 5.333% | 10.983% |
Relationships between endpoints
↥Index endpoint: H7_KERATITIS – Keratitis
GWS hits: 9
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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