No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1456 |
4. Check minimum number of eventsNone |
1456 |
5. Include endpointsNone |
1456 |
6. Filter based on genotype QC (FinnGen only) |
1404 |
Control definitions (FinnGen only)
Control exclude
H7_SCLERACORNEA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Herpesviral keratitis and keratoconjunctivitis
based on the number of shared cases.
Similar with more cases:
- Keratitis
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12217 | 6572 | 5592 |
| Only index persons | 11504 | 6258 | 5246 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.17 | 0.19 | 0.16 |
| Only index persons | 0.22 | 0.23 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 53.84 | 55.22 | 52.20 |
| Only index persons | 53.05 | 54.42 | 51.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1404 | 786 | 618 |
| Unadjusted period prevalence (%) | 0.31 | 0.31 | 0.31 |
| Median age at first event (years) | 55.68 | 53.11 | 58.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_HERPESKERATITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_HERPESKERATITIS | 1.265 [1.13, 1.41] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.337 |
During the follow-up period (1.1.1998 — 31.12.2019), 1095 out of 6103 females with H7_HERPESKERATITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_HERPESKERATITIS | 1.22 [1.09, 1.37] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 1073 out of 5181 males with H7_HERPESKERATITIS died.
Mortality risk
Mortality risk for people of age
years, who have H7_HERPESKERATITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.162% | 0.24% |
| 5 | 0.728% | 1.368% |
| 10 | 1.919% | 3.58% |
| 15 | 3.975% | 6.901% |
| 20 | 6.792% | 11.807% |
Relationships between endpoints
↥Index endpoint: H7_HERPESKERATITIS – Herpesviral keratitis and keratoconjunctivitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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