≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Other keratitis

DOID EFO Endpoint Browser PheWeb

H7_KERATITISOTH

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H16
  • Hospital discharge: ICD-9 — 370[2-5]
  • Hospital discharge: ICD-8 — 363|3600[1-2]|36905
  • Hospital discharge: excluded ICD-10 — H16.0
  • Hospital discharge: excluded ICD-8 — 36300
  • Cause of death: ICD-10 — H16
  • Cause of death: ICD-9 — 370[2-5]
  • Cause of death: ICD-8 — 363|3600[1-2]|36905
  • Cause of death: excluded ICD-10 — H16.0
  • Cause of death: excluded ICD-8 — 36300

2 out of 7 registries used, show all original rules.

4220

4. Check minimum number of events

None

4220

5. Include endpoints

None

4220

6. Filter based on genotype QC (FinnGen only)

4049

Control definitions (FinnGen only)

Control exclude H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF6
Parent code in ICD-10 H15-H22
Name in latin Keratitis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 41495 20035 21231
Only index persons 38043 18525 19518
Unadjusted period prevalence (%)
Whole population 0.58 0.57 0.59
Only index persons 0.71 0.68 0.75
Median age at first event (years)
Whole population 40.79 43.02 38.70
Only index persons 39.63 41.52 37.84

-FinnGen-

Key figures

All Female Male
Number of individuals 4049 2296 1753
Unadjusted period prevalence (%) 0.89 0.90 0.88
Median age at first event (years) 45.62 44.63 46.92

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint H7_KERATITISOTH and mortality.

Females

Parameter HR [95% CI] p-value
H7_KERATITISOTH 1.391 [1.23, 1.58] < 0.001
Birth year 0.993 [0.98, 1.0] 0.159

During the follow-up period (1.1.1998 — 31.12.2019), 1567 out of 15606 females with H7_KERATITISOTH died.

Males

Parameter HR [95% CI] p-value
H7_KERATITISOTH 1.319 [1.17, 1.48] < 0.001
Birth year 0.989 [0.98, 1.0] 0.039

During the follow-up period (1.1.1998 — 31.12.2019), 1650 out of 16393 males with H7_KERATITISOTH died.

Mortality risk

Mortality risk for people of age

years, who have H7_KERATITISOTH.

N-year risk Females Males
1 0.126% 0.275%
5 0.677% 1.572%
10 1.68% 4.15%
15 3.459% 7.631%
20 6.376% 12.644%

Relationships between endpoints

↥

Index endpoint: H7_KERATITISOTH – Other keratitis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data