No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
826 |
4. Check minimum number of eventsNone |
826 |
5. Include endpointsNone |
826 |
6. Filter based on genotype QC (FinnGen only) |
787 |
Control definitions (FinnGen only)
Control exclude
H7_SCLERACORNEA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H15-H22
Name in latin
Cicatrices et opacitates corneae
Similar endpoints
↥List of similar endpoints to
Corneal scars and opacities
based on the number of shared cases.
Similar with more cases:
- Keratitis
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7698 | 3908 | 3727 |
| Only index persons | 6810 | 3444 | 3366 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.11 | 0.10 |
| Only index persons | 0.13 | 0.13 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 61.16 | 67.07 | 54.84 |
| Only index persons | 59.45 | 65.16 | 53.60 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 787 | 402 | 385 |
| Unadjusted period prevalence (%) | 0.18 | 0.16 | 0.19 |
| Median age at first event (years) | 60.51 | 59.71 | 61.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEALSCAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALSCAR | 1.124 [0.99, 1.28] | 0.082 |
| Birth year | 0.992 [0.98, 1.0] | 0.07 |
During the follow-up period (1.1.1998 — 31.12.2019), 740 out of 2917 females with H7_CORNEALSCAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALSCAR | 1.186 [1.02, 1.38] | 0.028 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 559 out of 2918 males with H7_CORNEALSCAR died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEALSCAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.264% |
| 5 | 0.564% | 1.544% |
| 10 | 1.441% | 3.449% |
| 15 | 2.847% | 6.67% |
| 20 | 5.252% | 10.94% |
Relationships between endpoints
↥Index endpoint: H7_CORNEALSCAR – Corneal scars and opacities
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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