No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
823 |
4. Check minimum number of eventsNone |
823 |
5. Include endpoints |
861 |
6. Filter based on genotype QC (FinnGen only) |
823 |
Control definitions (FinnGen only)
Control exclude
H7_SCLERACORNEA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H15-H22
Name in latin
Aliae morbositates iridis et corporis ciliaris
Similar endpoints
↥List of similar endpoints to
Other disorders of iris and ciliary body
based on the number of shared cases.
Similar with more cases:
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8294 | 3671 | 4583 |
| Only index persons | 7402 | 3293 | 4109 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.11 | 0.13 |
| Only index persons | 0.14 | 0.12 | 0.16 |
| Median age at first event (years) | |||
| Whole population | 59.12 | 67.82 | 52.08 |
| Only index persons | 58.27 | 67.07 | 51.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 823 | 397 | 426 |
| Unadjusted period prevalence (%) | 0.19 | 0.16 | 0.21 |
| Median age at first event (years) | 62.34 | 61.59 | 63.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_OTHIRISCILIARY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OTHIRISCILIARY | 1.36 [1.18, 1.57] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.081 |
During the follow-up period (1.1.1998 — 31.12.2019), 834 out of 2998 females with H7_OTHIRISCILIARY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OTHIRISCILIARY | 1.515 [1.29, 1.78] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.024 |
During the follow-up period (1.1.1998 — 31.12.2019), 774 out of 3638 males with H7_OTHIRISCILIARY died.
Mortality risk
Mortality risk for people of age
years, who have H7_OTHIRISCILIARY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.073% | 0.389% |
| 5 | 0.65% | 1.978% |
| 10 | 1.761% | 4.879% |
| 15 | 3.416% | 9.112% |
| 20 | 6.018% | 15.387% |
Relationships between endpoints
↥Index endpoint: H7_OTHIRISCILIARY – Other disorders of iris and ciliary body
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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