Hyphaema and other vascular disorders of iris and ciliary body

H7_VASCCILIARY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H21.0, H21.1
  • Hospital discharge: ICD-9 3644
  • Cause of death: ICD-10 H21.0, H21.1
  • Cause of death: ICD-9 3644

2 out of 7 registries used, show all original rules.

616

4. Check minimum number of events

None

616

5. Include endpoints

None

616

6. Filter based on genotype QC (FinnGen only)

587

Control definitions (FinnGen only)

Control exclude H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5991 2454 3510
Only index persons 5469 2239 3230
Unadjusted period prevalence (%)
Whole population 0.09 0.07 0.10
Only index persons 0.11 0.08 0.12
Median age at first event (years)
Whole population 60.60 71.92 52.62
Only index persons 59.68 71.26 51.65

-FinnGen-

Key figures

All Female Male
Number of individuals 587 256 331
Unadjusted period prevalence (%) 0.14 0.10 0.17
Median age at first event (years) 65.09 65.44 64.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H7_VASCCILIARY and mortality.

Females

Parameter HR [95% CI] p-value
H7_VASCCILIARY 1.43 [1.22, 1.67] < 0.001
Birth year 0.998 [0.99, 1.01] 0.646

During the follow-up period (1.1.1998 — 31.12.2019), 674 out of 2047 females with H7_VASCCILIARY died.

Males

Parameter HR [95% CI] p-value
H7_VASCCILIARY 1.647 [1.36, 1.99] < 0.001
Birth year 0.986 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 628 out of 2837 males with H7_VASCCILIARY died.

Mortality risk

Mortality risk for people of age

years, who have H7_VASCCILIARY.

N-year risk Females Males
1 0.142% 0.259%
5 0.861% 1.779%
10 2.386% 4.403%
15 4.604% 8.327%
20 8.298% 13.714%

Relationships between endpoints

Index endpoint: H7_VASCCILIARY – Hyphaema and other vascular disorders of iris and ciliary body

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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