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Pupillary membranes and other adhesions and disruptions of iris and ciliary body

DOID EFO Endpoint Browser PheWeb

H7_ADHESIOIRIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H21.4, H21.5
  • Hospital discharge: ICD-9 — 3647
  • Hospital discharge: ICD-8 — 37831
  • Cause of death: ICD-10 — H21.4, H21.5
  • Cause of death: ICD-9 — 3647
  • Cause of death: ICD-8 — 37831

2 out of 7 registries used, show all original rules.

66

4. Check minimum number of events

None

66

5. Include endpoints

None

66

6. Filter based on genotype QC (FinnGen only)

66

Control definitions (FinnGen only)

Control exclude H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 849 383 459
Only index persons 678 307 371
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 58.21 67.48 50.24
Only index persons 57.65 67.48 49.52

-FinnGen-

Key figures

All Female Male
Number of individuals 66 29 37
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 61.66 62.45 61.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint H7_ADHESIOIRIS and mortality.

Females

Parameter HR [95% CI] p-value
H7_ADHESIOIRIS 1.018 [0.78, 1.33] 0.893
Birth year 0.993 [0.98, 1.0] 0.116

During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 298 females with H7_ADHESIOIRIS died.

Males

Parameter HR [95% CI] p-value
H7_ADHESIOIRIS 1.279 [0.92, 1.78] 0.144
Birth year 0.987 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 348 males with H7_ADHESIOIRIS died.

Mortality risk

Mortality risk for people of age

years, who have H7_ADHESIOIRIS.

N-year risk Females Males
1 0.083% 0.236%
5 0.665% 1.563%
10 1.45% 3.976%
15 2.724% 7.568%
20 4.764% 12.717%

Relationships between endpoints

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Index endpoint: H7_ADHESIOIRIS – Pupillary membranes and other adhesions and disruptions of iris and ciliary body

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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