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Other specified and unspecified disorders of iris and ciliary body

DOID Endpoint Browser PheWeb

H7_IRISCILIARYNAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H21.8, H21.9, H22.8*
  • Hospital discharge: ICD-9 — 364[8-9]
  • Cause of death: ICD-10 — H21.8, H21.9, H22.8*
  • Cause of death: ICD-9 — 364[8-9]

2 out of 7 registries used, show all original rules.

123

4. Check minimum number of events

None

123

5. Include endpoints

None

123

6. Filter based on genotype QC (FinnGen only)

116

Control definitions (FinnGen only)

Control exclude H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 973 537 432
Only index persons 839 470 369
Unadjusted period prevalence (%)
Whole population 0.01 0.02 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 54.03 56.06 51.59
Only index persons 53.90 55.91 51.36

-FinnGen-

Key figures

All Female Male
Number of individuals 116 75 41
Unadjusted period prevalence (%) 0.03 0.03 0.02
Median age at first event (years) 51.42 52.43 49.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint H7_IRISCILIARYNAS and mortality.

Females

Parameter HR [95% CI] p-value
H7_IRISCILIARYNAS 1.164 [0.86, 1.58] 0.327
Birth year 0.998 [0.99, 1.01] 0.68

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 413 females with H7_IRISCILIARYNAS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_IRISCILIARYNAS.

N-year risk Females Males
1 0.096% No data
5 0.77% No data
10 1.895% No data
15 3.663% No data
20 6.734% No data

Relationships between endpoints

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Index endpoint: H7_IRISCILIARYNAS – Other specified and unspecified disorders of iris and ciliary body

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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