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Acute and subacute iridocyclitis

DOID EFO Endpoint Browser PheWeb

H7_IRIDOACUTE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H20.0
  • Hospital discharge: ICD-9 — 3640
  • Hospital discharge: ICD-8 — 36400
  • Cause of death: ICD-10 — H20.0
  • Cause of death: ICD-9 — 3640
  • Cause of death: ICD-8 — 36400

2 out of 7 registries used, show all original rules.

7803

4. Check minimum number of events

None

7803

5. Include endpoints

None

7803

6. Filter based on genotype QC (FinnGen only)

7516

Control definitions (FinnGen only)

Control exclude H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF6
Parent code in ICD-10 H20
Name in latin Iridocyclitis acuta seu subacuta

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 65410 33303 31757
Only index persons 60364 31105 29259
Unadjusted period prevalence (%)
Whole population 0.92 0.95 0.89
Only index persons 1.13 1.14 1.12
Median age at first event (years)
Whole population 47.17 49.78 44.41
Only index persons 46.22 48.81 43.46

-FinnGen-

Key figures

All Female Male
Number of individuals 7516 4210 3306
Unadjusted period prevalence (%) 1.66 1.65 1.66
Median age at first event (years) 48.38 47.38 49.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_IRIDOACUTE and mortality.

Females

Parameter HR [95% CI] p-value
H7_IRIDOACUTE 1.067 [0.98, 1.17] 0.15
Birth year 0.99 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 3498 out of 27481 females with H7_IRIDOACUTE died.

Males

Parameter HR [95% CI] p-value
H7_IRIDOACUTE 1.06 [0.97, 1.16] 0.204
Birth year 0.989 [0.98, 1.0] 0.016

During the follow-up period (1.1.1998 — 31.12.2019), 3338 out of 25226 males with H7_IRIDOACUTE died.

Mortality risk

Mortality risk for people of age

years, who have H7_IRIDOACUTE.

N-year risk Females Males
1 0.098% 0.173%
5 0.49% 1.13%
10 1.302% 3.095%
15 2.554% 5.918%
20 4.395% 10.414%

Relationships between endpoints

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Index endpoint: H7_IRIDOACUTE – Acute and subacute iridocyclitis

GWS hits: 15

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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