corneal disease: A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3184 |
4. Check minimum number of eventsNone |
3184 |
5. Include endpoints |
3287 |
6. Filter based on genotype QC (FinnGen only) |
3150 |
Control definitions (FinnGen only)
Control exclude
H7_SCLERACORNEA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H15-H22
Name in latin
Aliae morbositates corneae
Similar endpoints
↥List of similar endpoints to
Other disorders of cornea
based on the number of shared cases.
Similar with more cases:
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 27514 | 14348 | 13021 |
| Only index persons | 25515 | 13289 | 12226 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.39 | 0.41 | 0.36 |
| Only index persons | 0.48 | 0.49 | 0.47 |
| Median age at first event (years) | |||
| Whole population | 52.38 | 59.94 | 44.18 |
| Only index persons | 51.37 | 58.67 | 43.44 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3150 | 1809 | 1341 |
| Unadjusted period prevalence (%) | 0.69 | 0.71 | 0.67 |
| Median age at first event (years) | 54.57 | 56.03 | 52.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEALOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALOTH | 1.079 [0.97, 1.2] | 0.167 |
| Birth year | 0.994 [0.99, 1.0] | 0.158 |
During the follow-up period (1.1.1998 — 31.12.2019), 1796 out of 10978 females with H7_CORNEALOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALOTH | 1.064 [0.93, 1.21] | 0.35 |
| Birth year | 0.985 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1173 out of 10027 males with H7_CORNEALOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEALOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.085% | 0.197% |
| 5 | 0.575% | 1.265% |
| 10 | 1.581% | 3.053% |
| 15 | 3.064% | 5.747% |
| 20 | 5.477% | 9.251% |
Relationships between endpoints
↥Index endpoint: H7_CORNEALOTH – Other disorders of cornea
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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