No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
248 |
4. Check minimum number of eventsNone |
248 |
5. Include endpointsNone |
248 |
6. Filter based on genotype QC (FinnGen only) |
238 |
Control definitions (FinnGen only)
Control exclude
H7_SCLERACORNEA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H18
Name in latin
Keratopathia bullosa
Similar endpoints
↥List of similar endpoints to
Bullous keratopathy
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Keratitis
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2359 | 1387 | 961 |
| Only index persons | 2101 | 1236 | 865 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 73.68 | 76.86 | 69.05 |
| Only index persons | 72.48 | 75.69 | 67.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 238 | 136 | 102 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | 70.30 | 70.31 | 70.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_BULLKERATOPATHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BULLKERATOPATHY | 1.232 [1.06, 1.43] | 0.006 |
| Birth year | 0.994 [0.99, 1.0] | 0.165 |
During the follow-up period (1.1.1998 — 31.12.2019), 547 out of 1262 females with H7_BULLKERATOPATHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BULLKERATOPATHY | 1.031 [0.86, 1.23] | 0.739 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 304 out of 869 males with H7_BULLKERATOPATHY died.
Mortality risk
Mortality risk for people of age
years, who have H7_BULLKERATOPATHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.201% |
| 5 | 0.61% | 1.199% |
| 10 | 1.702% | 3.042% |
| 15 | 3.265% | 5.816% |
| 20 | 6.012% | 9.836% |
Relationships between endpoints
↥Index endpoint: H7_BULLKERATOPATHY – Bullous keratopathy
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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