corneal edema: Hazy, swollen cornea.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
214 |
4. Check minimum number of eventsNone |
214 |
5. Include endpointsNone |
214 |
6. Filter based on genotype QC (FinnGen only) |
205 |
Control definitions (FinnGen only)
Control exclude
H7_SCLERACORNEA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H18
Name in latin
Aliud oedema corneae
Similar endpoints
↥List of similar endpoints to
Other corneal oedema
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2050 | 1197 | 844 |
| Only index persons | 1836 | 1082 | 754 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 73.26 | 75.52 | 70.07 |
| Only index persons | 72.97 | 75.20 | 69.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 205 | 117 | 88 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | 70.59 | 70.90 | 70.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEALOEDEMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALOEDEMA | 0.913 [0.77, 1.09] | 0.307 |
| Birth year | 0.991 [0.98, 1.0] | 0.037 |
During the follow-up period (1.1.1998 — 31.12.2019), 248 out of 903 females with H7_CORNEALOEDEMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALOEDEMA | 1.047 [0.8, 1.37] | 0.737 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 602 males with H7_CORNEALOEDEMA died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEALOEDEMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.206% |
| 5 | 0.425% | 1.229% |
| 10 | 1.105% | 3.074% |
| 15 | 2.166% | 5.816% |
| 20 | 4.016% | 9.612% |
Relationships between endpoints
↥Index endpoint: H7_CORNEALOEDEMA – Other corneal oedema
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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