No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
432 |
4. Check minimum number of eventsNone |
432 |
5. Include endpointsNone |
432 |
6. Filter based on genotype QC (FinnGen only) |
421 |
Control definitions (FinnGen only)
Control exclude
H7_SCLERACORNEA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H18
Name in latin
Degeneratio corneae
Similar endpoints
↥List of similar endpoints to
Corneal degeneration
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3016 | 1902 | 1102 |
| Only index persons | 2762 | 1757 | 1005 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.03 |
| Only index persons | 0.06 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 65.63 | 67.79 | 62.16 |
| Only index persons | 64.93 | 66.76 | 61.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 421 | 276 | 145 |
| Unadjusted period prevalence (%) | 0.10 | 0.11 | 0.07 |
| Median age at first event (years) | 63.77 | 62.20 | 66.78 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEALDYSTROPHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALDYSTROPHY | 1.201 [1.0, 1.44] | 0.048 |
| Birth year | 0.994 [0.99, 1.0] | 0.189 |
During the follow-up period (1.1.1998 — 31.12.2019), 286 out of 1316 females with H7_CORNEALDYSTROPHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALDYSTROPHY | 1.171 [0.91, 1.51] | 0.228 |
| Birth year | 0.993 [0.98, 1.0] | 0.137 |
During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 781 males with H7_CORNEALDYSTROPHY died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEALDYSTROPHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.133% | 0.305% |
| 5 | 0.783% | 1.513% |
| 10 | 1.754% | 3.959% |
| 15 | 3.484% | 7.537% |
| 20 | 5.907% | 13.452% |
Relationships between endpoints
↥Index endpoint: H7_CORNEALDYSTROPHY – Corneal degeneration
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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