No definition available.
Disorders of lipoprotein metabolism and other lipidaemias
DOID EFO Endpoint Browser PheWeb
E4_LIPOPROT
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
52514 |
4. Check minimum number of eventsNone |
52514 |
5. Include endpoints |
52879 |
6. Filter based on genotype QC (FinnGen only) |
50955 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E70-E90
Name in latin
Perturbationes metabolismi lipoproteinorum et aliae lipidaemiae
Disorders of lipoprotein metabolism and other lipidaemias
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 398449 | 188303 | 209042 |
| Only index persons | 382836 | 182541 | 200295 |
| Unadjusted period prevalence (%) | |||
| Whole population | 5.62 | 5.39 | 5.84 |
| Only index persons | 7.20 | 6.71 | 7.65 |
| Median age at first event (years) | |||
| Whole population | 67.97 | 70.89 | 65.36 |
| Only index persons | 67.99 | 70.85 | 65.39 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 50955 | 22827 | 28128 |
| Unadjusted period prevalence (%) | 11.81 | 8.97 | 14.13 |
| Median age at first event (years) | 66.22 | 66.98 | 65.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_LIPOPROT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_LIPOPROT | 1.241 [1.13, 1.36] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.107 |
During the follow-up period (1.1.1998 — 31.12.2019), 33321 out of 150079 females with E4_LIPOPROT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_LIPOPROT | 1.327 [1.2, 1.47] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 37803 out of 167231 males with E4_LIPOPROT died.
Mortality risk
Mortality risk for people of age
years, who have E4_LIPOPROT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.224% |
| 5 | 0.587% | 1.361% |
| 10 | 1.487% | 3.347% |
| 15 | 2.85% | 6.443% |
| 20 | 4.88% | 10.784% |
Relationships between endpoints
↥Index endpoint: E4_LIPOPROT – Disorders of lipoprotein metabolism and other lipidaemias
GWS hits: 45
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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