No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
743 |
4. Check minimum number of eventsNone |
743 |
5. Include endpointsNone |
743 |
6. Filter based on genotype QC (FinnGen only) |
707 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E78
Name in latin
Hypertriglyceridaemia pura
Similar endpoints
↥List of similar endpoints to
Pure hyperglyceridaemia
based on the number of shared cases.
Similar with more cases:
- Disorders of lipoprotein metabolism and other lipidaemias
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5770 | 2211 | 3519 |
| Only index persons | 5271 | 2040 | 3231 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.06 | 0.10 |
| Only index persons | 0.10 | 0.07 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 60.41 | 67.97 | 55.72 |
| Only index persons | 60.07 | 67.69 | 55.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 707 | 252 | 455 |
| Unadjusted period prevalence (%) | 0.18 | 0.10 | 0.23 |
| Median age at first event (years) | 57.87 | 59.99 | 56.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERGLYCER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERGLYCER | 1.744 [1.49, 2.04] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 592 out of 1826 females with E4_HYPERGLYCER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERGLYCER | 1.701 [1.46, 1.98] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 628 out of 2695 males with E4_HYPERGLYCER died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERGLYCER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.138% | 0.306% |
| 5 | 0.801% | 2.134% |
| 10 | 1.861% | 5.326% |
| 15 | 3.869% | 9.828% |
| 20 | 6.775% | 16.051% |
Relationships between endpoints
↥Index endpoint: E4_HYPERGLYCER – Pure hyperglyceridaemia
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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