Disorder of lipoprotein metabolism, unspecified

E4_LIPOPROTNAS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E78.8, E78.8+M14.3, E78.9
  • Hospital discharge: ICD-9 272[7-9]
  • Hospital discharge: ICD-8 27288|2729
  • Cause of death: ICD-10 E78.8, E78.8+M14.3, E78.9
  • Cause of death: ICD-9 272[7-9]
  • Cause of death: ICD-8 27288|2729

2 out of 7 registries used, show all original rules.

5098

4. Check minimum number of events

None

5098

5. Include endpoints

None

5098

6. Filter based on genotype QC (FinnGen only)

4894

Control definitions (FinnGen only)

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 35890 16241 19519
Only index persons 34064 15569 18495
Unadjusted period prevalence (%)
Whole population 0.51 0.47 0.55
Only index persons 0.64 0.57 0.71
Median age at first event (years)
Whole population 67.40 70.76 64.61
Only index persons 67.34 70.61 64.60

-FinnGen-

Key figures

All Female Male
Number of individuals 4894 1997 2897
Unadjusted period prevalence (%) 1.18 0.78 1.45
Median age at first event (years) 65.23 65.81 64.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint E4_LIPOPROTNAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_LIPOPROTNAS 1.356 [1.24, 1.48] < 0.001
Birth year 0.996 [0.99, 1.0] 0.346

During the follow-up period (1.1.1998 — 31.12.2019), 4301 out of 14342 females with E4_LIPOPROTNAS died.

Males

Parameter HR [95% CI] p-value
E4_LIPOPROTNAS 1.389 [1.26, 1.53] < 0.001
Birth year 0.983 [0.97, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 4907 out of 17226 males with E4_LIPOPROTNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_LIPOPROTNAS.

N-year risk Females Males
1 0.161% 0.244%
5 0.905% 1.453%
10 2.244% 3.514%
15 4.322% 6.696%
20 7.342% 11.126%

Relationships between endpoints

Index endpoint: E4_LIPOPROTNAS – Disorder of lipoprotein metabolism, unspecified

GWS hits: 10

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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