No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
66 |
4. Check minimum number of eventsNone |
66 |
5. Include endpointsNone |
66 |
6. Filter based on genotype QC (FinnGen only) |
61 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E78
Name in latin
Deficientia lipoproteinorum
Similar endpoints
↥List of similar endpoints to
Lipoprotein deficiency
based on the number of shared cases.
Similar with more cases:
- Disorders of lipoprotein metabolism and other lipidaemias
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 675 | 279 | 394 |
| Only index persons | 614 | 256 | 358 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 65.75 | 68.29 | 63.94 |
| Only index persons | 65.71 | 68.17 | 63.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 61 | 21 | 40 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 61.37 | 60.01 | 62.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_LIPODEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_LIPODEF | 2.042 [1.38, 3.01] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.377 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 249 females with E4_LIPODEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_LIPODEF | 2.28 [1.56, 3.33] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 343 males with E4_LIPODEF died.
Mortality risk
Mortality risk for people of age
years, who have E4_LIPODEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.166% | 0.293% |
| 5 | 1.201% | 2.475% |
| 10 | 3.159% | 6.698% |
| 15 | 5.917% | 12.738% |
| 20 | 10.015% | 20.311% |
Relationships between endpoints
↥Index endpoint: E4_LIPODEF – Lipoprotein deficiency
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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