No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
68 |
4. Check minimum number of eventsNone |
68 |
5. Include endpointsNone |
68 |
6. Filter based on genotype QC (FinnGen only) |
67 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E78
Name in latin
Hyperchylomicronaemia
Similar endpoints
↥List of similar endpoints to
Hyperchylomicronaemia
based on the number of shared cases.
Similar with more cases:
- Disorders of lipoprotein metabolism and other lipidaemias
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 525 | 214 | 310 |
| Only index persons | 487 | 196 | 291 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 61.99 | 67.95 | 57.98 |
| Only index persons | 61.43 | 66.74 | 57.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 67 | 24 | 43 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 57.25 | 61.02 | 55.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERCHYLO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERCHYLO | 1.618 [1.15, 2.27] | 0.005 |
| Birth year | 0.996 [0.99, 1.0] | 0.346 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 185 females with E4_HYPERCHYLO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERCHYLO | 1.441 [1.03, 2.02] | 0.035 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 72 out of 267 males with E4_HYPERCHYLO died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERCHYLO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.18% | 0.268% |
| 5 | 0.987% | 1.735% |
| 10 | 2.419% | 4.267% |
| 15 | 4.531% | 7.504% |
| 20 | 8.32% | 12.569% |
Relationships between endpoints
↥Index endpoint: E4_HYPERCHYLO – Hyperchylomicronaemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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