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Hyperlipidaemia, other/unspecified

DOID EFO Endpoint Browser PheWeb

E4_HYPERLIPNAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

16186

4. Check minimum number of events

None

16186

5. Include endpoints

None

16186

6. Filter based on genotype QC (FinnGen only)

15522

Control definitions (FinnGen only)

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 120574 53798 66469
Only index persons 116174 52282 63892
Unadjusted period prevalence (%)
Whole population 1.71 1.54 1.86
Only index persons 2.21 1.92 2.44
Median age at first event (years)
Whole population 67.74 70.72 65.34
Only index persons 67.71 70.64 65.31

-FinnGen-

Key figures

All Female Male
Number of individuals 15522 6528 8994
Unadjusted period prevalence (%) 3.70 2.56 4.52
Median age at first event (years) 66.07 67.01 65.39

-FinRegistry-

Age distribution of first events

01020304050607080900k5k10k15k20k25k30k35kAgeIndividuals

-FinnGen-

Age distribution of first events

01020304050607080900.0k0.5k1.0k1.5k2.0k2.5k3.0k3.5k4.0k4.5kAgeIndividuals

-FinRegistry-

Year distribution of first events

1970197519801985199019952000200520102015202020220k5k10k15k20k25k30kYearIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952000200520102015202020230.0k0.5k1.0k1.5k2.0k2.5k3.0k3.5k4.0kYearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000123456789AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

0102030405060708090100012345678910111213AgeProbability of first incidence (%)

Mortality – FinRegistry

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Association

Association between endpoint E4_HYPERLIPNAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_HYPERLIPNAS 1.165 [1.06, 1.28] 0.001
Birth year 0.995 [0.99, 1.0] 0.243

During the follow-up period (1.1.1998 — 31.12.2019), 10429 out of 45459 females with E4_HYPERLIPNAS died.

Males

Parameter HR [95% CI] p-value
E4_HYPERLIPNAS 1.227 [1.11, 1.36] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 13142 out of 56206 males with E4_HYPERLIPNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_HYPERLIPNAS.

N-year risk Females Males
1 0.131% 0.161%
5 0.714% 1.224%
10 1.853% 3.317%
15 3.355% 6.239%
20 5.904% 10.686%

Relationships between endpoints

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Index endpoint: E4_HYPERLIPNAS – Hyperlipidaemia, other/unspecified

GWS hits: 21

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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