No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
16186 |
4. Check minimum number of eventsNone |
16186 |
5. Include endpointsNone |
16186 |
6. Filter based on genotype QC (FinnGen only) |
15522 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Hyperlipidaemia, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Disorders of lipoprotein metabolism and other lipidaemias
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 120574 | 53798 | 66469 |
| Only index persons | 116174 | 52282 | 63892 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.71 | 1.54 | 1.86 |
| Only index persons | 2.21 | 1.92 | 2.44 |
| Median age at first event (years) | |||
| Whole population | 67.74 | 70.72 | 65.34 |
| Only index persons | 67.71 | 70.64 | 65.31 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 15522 | 6528 | 8994 |
| Unadjusted period prevalence (%) | 3.70 | 2.56 | 4.52 |
| Median age at first event (years) | 66.07 | 67.01 | 65.39 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERLIPNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERLIPNAS | 1.165 [1.06, 1.28] | 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.243 |
During the follow-up period (1.1.1998 — 31.12.2019), 10429 out of 45459 females with E4_HYPERLIPNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERLIPNAS | 1.227 [1.11, 1.36] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 13142 out of 56206 males with E4_HYPERLIPNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERLIPNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.131% | 0.161% |
| 5 | 0.714% | 1.224% |
| 10 | 1.853% | 3.317% |
| 15 | 3.355% | 6.239% |
| 20 | 5.904% | 10.686% |
Relationships between endpoints
↥Index endpoint: E4_HYPERLIPNAS – Hyperlipidaemia, other/unspecified
GWS hits: 21
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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