hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
705 |
4. Check minimum number of eventsNone |
705 |
5. Include endpoints |
763 |
6. Filter based on genotype QC (FinnGen only) |
733 |
Control definitions (FinnGen only)
Control exclude
D3_HAEMOLYTICANAEMIA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D55-D59
Name in latin
Anaemia haemolytica acquisita
Similar endpoints
↥List of similar endpoints to
Acquired haemolytic anaemia
based on the number of shared cases.
Similar with more cases:
- Haemolytic anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7041 | 3819 | 3130 |
| Only index persons | 4923 | 2698 | 2225 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.11 | 0.09 |
| Only index persons | 0.09 | 0.10 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 65.04 | 66.51 | 63.16 |
| Only index persons | 61.86 | 62.50 | 61.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 733 | 367 | 366 |
| Unadjusted period prevalence (%) | 0.16 | 0.14 | 0.18 |
| Median age at first event (years) | 61.19 | 55.60 | 66.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_ACQHAEMOLYTICANAEMIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACQHAEMOLYTICANAEMIA | 2.809 [2.38, 3.31] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.164 |
During the follow-up period (1.1.1998 — 31.12.2019), 1010 out of 2437 females with D3_ACQHAEMOLYTICANAEMIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACQHAEMOLYTICANAEMIA | 2.96 [2.45, 3.58] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.112 |
During the follow-up period (1.1.1998 — 31.12.2019), 846 out of 2047 males with D3_ACQHAEMOLYTICANAEMIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_ACQHAEMOLYTICANAEMIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.258% | 0.614% |
| 5 | 1.926% | 3.519% |
| 10 | 4.031% | 8.893% |
| 15 | 7.254% | 17.108% |
| 20 | 12.953% | 28.787% |
Relationships between endpoints
↥Index endpoint: D3_ACQHAEMOLYTICANAEMIA – Acquired haemolytic anaemia
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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