anemia (phenotype): ['A reduction in the number of circulating erythrocytes or in the quantity of hemoglobin.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
35158 |
6. Filter based on genotype QC (FinnGen only) |
33700 |
Control definitions (FinnGen only)
Control exclude
NEURO_COMORBIDITIES
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Anaemias
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 365122 | 211544 | 149064 |
| Only index persons | 279710 | 168187 | 111523 |
| Unadjusted period prevalence (%) | |||
| Whole population | 5.27 | 6.06 | 4.16 |
| Only index persons | 5.42 | 6.18 | 4.26 |
| Median age at first event (years) | |||
| Whole population | 68.58 | 68.34 | 68.93 |
| Only index persons | 66.23 | 65.00 | 68.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 33700 | 17963 | 15737 |
| Unadjusted period prevalence (%) | 7.45 | 7.05 | 7.90 |
| Median age at first event (years) | 63.08 | 57.19 | 69.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_ANAEMIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ANAEMIA | 2.291 [2.1, 2.5] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 59306 out of 140052 females with D3_ANAEMIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ANAEMIA | 2.714 [2.45, 3.01] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 51966 out of 102893 males with D3_ANAEMIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_ANAEMIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.181% | 0.392% |
| 5 | 1.032% | 2.51% |
| 10 | 2.579% | 5.743% |
| 15 | 4.712% | 11.072% |
| 20 | 7.851% | 17.92% |
Relationships between endpoints
↥Index endpoint: D3_ANAEMIA – Anaemias
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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